Acromegaly is caused by the uncontrolled hypersecretion of growth hormone (GH) by the pituitary, a tiny gland — about the size of a pea –– located just below your brain, behind your eyes. The pituitary is also known as the "master gland" — this is because it controls multiple functions, including normal growth, metabolism, and reproductive activity. In most cases, the cause of this excessive production of GH is a noncancerous tumor on the pituitary. This pituitary tumor secretes a high level of GH, causing the enlargement of many body parts, such as the hands and feet. Because of where it is located, this tumor can also cause headaches with pressure behind the eyes.
Understanding the Causes of Acromegaly
There are 3 important hormones that circulate throughout your body that regulate many of the most basic activities of your body. These hormones play a key role in acromegaly: