Acromegaly
Treatment Options

Treating acromegaly effectively often relies on a multi-modal strategy that includes surgery, medical therapy, and/or radiation.

Surgical Management of Acromegaly

Surgery should be considered first-line therapy for all acromegaly patients. However, research shows that remission with surgery is based on multiple factors, including whether the patient presents with a macroadenoma or a microadenoma. Patients with a microadenoma have > 85% chance of initial remission with surgery, whereas for those with macroadenoma, the chances of remission are lower — about 40-50%.1 Regardless of tumor type, even if the mass is removed and the patient is initially cured it's important to note that the tumor can grow back –– so ongoing monitoring of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels is vital.2


Surgical intervention aims to provide the following:3
  • Immediate reduction in GH levels
  • Elimination of the tumor mass and reversal of associated symptoms, including headache and visual impairment
  • Alleviation of comorbidities such as hypertension, sleep apnea, arthritis, etc.
  • Preservation of pituitary function and restoration of endocrine deficits caused by the tumor
  • Prevention of tumor recurrence
  • Ability to retrieve and test tissue

Transsphenoidal surgery, which is standard treatment and causes less morbidity than transcranial procedures, can be achieved by two approaches. The two different types of transsphenoidal surgery are: 3,4

  • Translabial (surgery to reach the pituitary through an incision through the upper lip) which offers the surgeon improved visibility but is more invasive
  • Transnasal (surgery to reach the pituitary through the nose) which provides less discomfort for the patient but has limited visibility and may be more appropriate for smaller pituitary tumors

With all surgical approaches in acromegaly, the surgeon's expertise is critical to a successful outcome.

Medical Therapy

Medical therapy treatment options include:


  • Somatostatin Analogues
  • Dopamine Agonists
  • GH Receptor Antagonists

Radiation Therapy

According to the AACE Guidelines, radiation is most commonly used in acromegaly as adjuvant therapy after surgical removal of a tumor.3 However, the full effect of this therapy may not occur for many years.2



References:
1.
Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(11):3933-51.
2.
National Institute of Diabetes and Digestive and Kidney Diseases. Acromegaly. Available at: www.endocrine.niddk.nih.gov/pubs/acro/Acromegaly.pdf - 06-10-2008. Accessed June 11, 2009.
3.
American Association of Clinical Endocrinologists Medical guidelines for clinical practice for the diagnosis and treatment of acromegaly. Endocrine Practice. 2004;10:213-225.
4.
Thorner MO, Vance ML, Laws ER, Horvath E, Kovacs K. The Anterior Pituitary. In: Wilson JD, Foster DW (eds) Williams Textbook of Endocrinology. 9th ed. Philadelphia, Pa.: WB Saunders Company; 1998:234–249
5.
Melmed S, Casanueva F, Cavagnini F, Chanson P, et al. Consensus statement: Medical management of acromegaly. Eur J Endocrinol. 2005;153:737-740.